Technological advances, together with a better understanding of the molecular biology of infectious microorganisms, are creating exciting possibilities for a new generation of replicating vaccines. Historically, live vaccines have been either directly derived from a natural source or attenuated by empirical approaches using serial passages and host cell adaptation. Currently, we are witnessing a quantum leap in our technological capabilities to specifically modify the genetic make-up of viruses and bacteria, making it possible to generate improved live vaccines and to develop completely new types of replicating vaccines, such as vectored vaccines, single-round infectious vaccines and replicon vaccines. This book highlights some of the most exciting recent developments towards a new generation of replicating vaccines.Gu J, Korteweg C (2007) Pathology and pathogenesis of severe acute respiratory syndrome. ... between the occurrence of undifferentiated bovine respiratory disease and titer changes to bovine coronavirus and bovine viral diarrhea virus in 3anbsp;...
Title | : | Replicating Vaccines |
Author | : | Philip Dormitzer, Christian W. Mandl, Rino Rappuoli |
Publisher | : | Springer Science & Business Media - 2010-11-02 |
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